As a general rule of thumb, never take CBD with any medication that has the “grapefruit warning” which informs patients not to eat grapefruit/grapefruit juice while taking a certain medication. Like grapefruit, CBD can have an impact on how medicine is metabolized by your body. CBD significantly inhibits CYP450 enzymes (or cytochromes p450) and causes them to bind inside your intestines and your liver, which can cause a much higher dose of medication to circulate into your systematic blood stream. With certain medications, this higher dose can cause an overdose; an overdose, depending on the medication being used, can cause serious complications.
The research on CBD interactions is needed, as it’s not uncommon for some epilepsy patients to take CBD with more traditional anticonvulsant drugs. "While this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of," she said. The University of Alabama at Birmingham’s prospective, compassionate-use study was created to assess CBD’s safety and potential as an add-on therapy for treatment-resistant epilepsy. And it includes frequent monitoring of serum AED levels in case of any drug–drug interactions.
High-THC cannabis is going to give the user an intense psychoactive experience, and while antipsychotic drugs may be considered a good way to moderate these effects, there’s one major issue. The sedating nature of both could make the user over-sedated and make them physically distressed. If you have concerns about the medication that you are taking – or want to take – with cannabis, then discussing with your doctor is the best step. However, for common prescription drugs, you may be able to find some helpful information on MedScape’s Drug Interaction Checker. Consult a medical professional if you’re considering making adjustments to your medication.
It is extensively metabolized in the liver by CYP3A4 with CYP2D6 also playing a minor roll. As such, it may interact with CBD, possibly increasing unwanted side effects. Prescription strength NSAIDs are also commonly metabolized by CYP450 enzymes.
Among these metabolites, 6α-OH-, 6β-OH-, 7-OH-, and 4″-OH-CBDs were the major ones as estimated from the relative abundance of m/z 478, which was a predominant fragment ion of trimethylsilyl derivatives of the metabolites. Seven of 14 recombinant human CYP enzymes examined (CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) were capable of metabolizing CBD. The correlation and inhibition studies also showed that CBD 6α-hydroxylation was mainly catalyzed by CYP3A4 and CYP2C19, whereas CBD 7-hydroxylation was predominantly catalyzed by CYP2C19. This study indicated that CBD was extensively metabolized by HLMs. These results suggest that CYP3A4 and CYP2C19 may be major isoforms responsible for 6α-, 6β-, 7-, and/or 4″-hydroxylations of CBD in HLMs.
Many over-the-counter medicines are metabolized by CYP450 enzymes. Do not combine these medications with CBD without medical supervision. Benzodiazepines are metabolized by CYP450 enzymes and carry grapefruit warnings.
Many vape shops now stock a variety of premium CBD liquids, possibly even some tinctures and edibles. Just make sure you are getting pure CBD oil and not hemp seed oil, learn the difference. Cannabis dispensaries also tend to carry full spectrum CBD oil, but most of them contain higher ratios of THC to CBD, which is known to produce psychoactive effects.
Checking blood pressure while consuming cannabis might be a good idea for patients under any kind of antihypertensive treatments. Antihistamines used in the treatment of allergy-related symptoms like sneezing and runny nose can interact with the cannabis phytocomplex too. Drugs containing loratadine, fexofenadine, diphenhydramine, or similar antihistamines’ compounds can cause drowsiness as a side effect. When combined with cannabis, this adverse effect becomes potentiated. Tachycardia is another possible side effect of mixing antihistamines drugs with cannabis.
Objective To map the available evidence on the efficacy and safety of medicinal cannabis in children and adolescents. Methods We conducted a scoping hemp oil benefits review and searched six electronic databases and grey literature. A study was eligible for inclusion when it investigated the efficacy or safety of medicinal cannabis for any condition, more than half of the participants were 0 to 18 years old, and had any study design except single case reports. Results We included 36 studies in our final analysis, 32 of which investigated the efficacy or safety of cannabis in treatment-resistant epilepsy.